Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response.

@article{Li2011FucoidanAS,
  title={Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response.},
  author={Chunmei Li and Yonglin Gao and Y. Xing and Haibo Zhu and Jingyu Shen and J. Tian},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2011},
  volume={49 9},
  pages={
          2090-5
        }
}
  • Chunmei Li, Yonglin Gao, +3 authors J. Tian
  • Published 2011
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The aim of the study was to determine the effects of fucoidan on rat myocardial ischemia-reperfusion (I/R) model and elucidate the potential mechanisms. Myocardial I/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 2h. After 2h reperfusion, hemodynamics parameters were detected. Blood samples were collected to determine serum levels of tumor necrosis factor-α (TNF-α) and interleukin 6, 10 (IL-6, 10). Hearts were harvested… Expand
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