Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-alpha and nitric oxide from murine macrophages.

@article{Mizuno2000FucogalactanIF,
  title={Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-alpha and nitric oxide from murine macrophages.},
  author={Masashi Mizuno and Yasushi Shiomi and Keiko Minato and Sachiko Kawakami and Hitoshi Ashida and Hiroki Tsuchida},
  journal={Immunopharmacology},
  year={2000},
  volume={46 2},
  pages={113-21}
}
Eight species of mushrooms were evaluated for mitogenic activity by the tetrazolium salt 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method using spleen cells of C3H/HeN female mice. The hot water-soluble (HWS) fraction extracted from Sarcodon aspratus showed the highest activity. The mitogen in Sa. aspratus was isolated by Sepharose 6B and DEAE-Sepharose CL-6B column chromatography. Preliminary structural analyses indicated that the mitogen was a fucogalactan… CONTINUE READING
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