Fucan effect on CHO cell proliferation and migration.

  title={Fucan effect on CHO cell proliferation and migration.},
  author={Leonardo Thiago Duarte Barreto Nobre and Arthur Anthunes Jacome Vidal and Jailma Almeida-Lima and Ruth Medeiros de Oliveira and Edgar Jean Paredes-Gamero and Valquiria Pereira de Medeiros and Edvaldo da Silva Trindade and C{\'e}lia Regina Cavichiolo Franco and Helena B. Nader and Hugo Alexandre Oliveira Rocha},
  journal={Carbohydrate polymers},
  volume={98 1},
Fucan is a term used to denominate sulfated L-fucose rich polysaccharides. Here, a heterofucan, named fucan B, was extracted from the Spatoglossum schröederi seaweed. This 21.5 kDa galactofucan inhibited CHO-K1 proliferation and migration when fibronectin was the substrate. Fucan B derivatives revealed that such effects depend on their degree of sulfation. Fucan B did not induce cell death, but promoted G1 cell cycle arrest. Western blotting and flow cytometry analysis suggest that fucan B… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 33 references

For - mation of an adherent hematopoietic expansion culture using fucoidan

M. R. rhimeh, J. H. Fitton, K. H. Ko, R. M. Lowenthal, R. E. Nordon
Annals of Hematology • 2011

Similar Papers

Loading similar papers…