Fruit polyphenols, immunity and inflammation

  title={Fruit polyphenols, immunity and inflammation},
  author={Javier Gonz{\'a}lez‐Gallego and Mar{\'i}a Victoria Garc{\'i}a‐Mediavilla and Sonia S{\'a}nchez-Campos and Mar{\'i}a Jes{\'u}s Tu{\~n}{\'o}n},
  journal={British Journal of Nutrition},
  pages={S15 - S27}
Flavonoids are a large class of naturally occurring compounds widely present in fruits, vegetables and beverages derived from plants. These molecules have been reported to possess a wide range of activities in the prevention of common diseases, including CHD, cancer, neurodegenerative diseases, gastrointestinal disorders and others. The effects appear to be related to the various biological/pharmacological activities of flavonoids. A large number of publications suggest immunomodulatory and… 

Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

Recent findings on the bioavailability and biological activity of (poly)phenols are summarized, focusing on the epidemiological and clinical evidence of beneficial effects of flavonoids and related compounds on urinary tract infections, cognitive function and age-related cognitive decline, cancer and cardiovascular disease.

Recent Advances in Biologically Active Compounds in Herbs and Spices: A Review of the Most Effective Antioxidant and Anti-Inflammatory Active Principles

An attempt has been made to summarize the most current scientific evidence about the in vitro and in vivo effects of the bioactive compounds derived from herbs and spices, focused on anti-inflammatory and antioxidant effects, in order to provide science-based evidence for the traditional uses and develop either functional foods or nutraceuticals.

Analysis and Antioxidant Capacity of Anthocyanin Pigments. Part I: General Considerations Concerning Polyphenols and Flavonoids

Many epidemiological studies have shown the benefits of a diet rich in fruit and vegetables to human health and for the prevention of various diseases associated with oxidative stress, such as cancer

Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?

  • S. Chirumbolo
  • Biology
    Journal of the science of food and agriculture
  • 2012
Several polyphenolic compounds, which are commonly found in vegetables, fruits and plant-derived juices or beverages, exert well-evidenced cardioprotective, neuroprotective, chemopreventive and anti-inflammatory properties, but, nevertheless, further clinical and epidemiological research is required.

Role of Flavonoids in Management of Inflammatory Disorders

Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis.

Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis.



Flavonoids in Food and Their Health Benefits

The current advances in flavonoids in food is reviewed, with emphasis on health aspects on the basis of the published literature, which may provide some guidance for researchers in further investigations and for industries in developing practical health agents.

Anti-inflammatory plant flavonoids and cellular action mechanisms.

The effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes are summarized and a potential for new anti-inflammatory agents are discussed.

The effects of phenolic components of tea on the production of pro- and anti-inflammatory cytokines by human leukocytes in vitro.

Although these effects suggest anti-inflammatory properties of the tea-derived catechins, they were observed at concentrations which were unlikely to be achievable in plasma in vivo and are therefore unlikely to contribute to the protective effects of tea- derived flavonoids in inflammatory diseases.

Cocoa: antioxidant and immunomodulator

It is suggested that high-dose cocoa intake in young rats favours the T helper 1 (Th1) response and increases intestinal γδ T lymphocyte count, whereas the antibody-secreting response decreases.

Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways.

The present review summarizes recent research data focusing on the modulation of the expression of different inflammatory mediators by flavonoids and the effects on cell signaling pathways responsible for their anti-inflammatory activity.

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

  • J. HigdonB. Frei
  • Chemistry, Medicine
    Critical reviews in food science and nutrition
  • 2003
The effects of tea and green tea catechins on biomarker of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited.

Immunity and antioxidant capacity in humans is enhanced by consumption of a dried, encapsulated fruit and vegetable juice concentrate.

FVJC consumption during this study period resulted in increased plasma nutrients and antioxidant capacity, reduction in DNA strand breaks, and an increase in circulating gammadelta-T cells.

Absorption, metabolism, and antioxidant effects of pomegranate (Punica granatum l.) polyphenols after ingestion of a standardized extract in healthy human volunteers.

Overall, this study demonstrated the absorbability of EA from a pomegranate extract high in ellagitannin content and its ex vivo antioxidant effects.

Flavonoids and Colorectal Cancer in Italy

Support is provided for an inverse association of selected classes of flavonoids with colorectal cancer risk using recently published data on the composition of foods and beverages, in terms of six principal classes of Flavonoids, on dietary information collected through a validated food-frequency questionnaire.