Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.

@article{Caton2011FructoseIG,
  title={Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.},
  author={Paul Caton and Nanda K Nayuni and Noorafza Q. Khan and Elizabeth G. Wood and Roger Corder},
  journal={The Journal of endocrinology},
  year={2011},
  volume={208 3},
  pages={273-83}
}
Consumption of a fructose-rich diet leads to insulin resistance and dyslipidemia in part due to elevated gluconeogenesis and lipogenesis. SIRT1, an NAD(+)-dependent protein deacetylase, can induce gluconeogenesis and lipogenesis. The aim of this study was to determine whether fructose increased hepatic SIRT1, leading to induction of gluconeogenesis and lipogenesis. Rat hepatocytes were incubated with fructose (1-5 mM). SIRT1 protein, SIRT1 activity, and NAD(+)/NADH ratio were measured. The… CONTINUE READING

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