• DOI:10.1152/AJPRENAL.00124.2006
• Corpus ID: 13965775

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.

@article{SnchezLozada2007FructoseinducedMS,
  title={Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.},
  author={Laura Gabriela S{\'a}nchez-Lozada and Edilia Tapia and Adriana Jim{\'e}nez and Pablo Bautista and Magdalena Crist{\'o}bal and Tom{\'a}s Nepomuceno and Virgilia Soto and Carmen {\'A}vila-Casado and Takahiko Nakagawa and Richard J. Johnson and Jaime Herrera-Acosta and Martha Franco},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 1},
  pages={
          F423-9
        }
}

• L. Sánchez-Lozada, E. Tapia, +9 authors Martha Franco
• Published 2007
• Medicine, Biology
• American journal of physiology. Renal physiology

Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn, the metabolic syndrome has been epidemiologically linked with renal progression. The renal hemodynamic effects of fructose intake are unknown, as well as the effects of different routes of administration. Metabolic syndrome was induced in rats over 8 wk by either a high-fructose diet (60%, F60, n = 7) or by adding fructose to drinking water (10%, F10, n = 7). Body weight and food and fluid intake of each rat were measured weekly during the follow-up. At baseline and at the end of wk 8, systolic blood pressure, plasma uric acid, and triglycerides were measured. At the end of week 8 glomerular hemodynamics was evaluated by micropuncture techniques. Wall thickening in outer cortical and juxtamedullary afferent arterioles was assessed by immunohistochemistry and computer image analysis. Fructose administration either in diet or drinking water induced hypertension, hyperuricemia, and hypertriglyceridemia; however, there was a progressive increment in these parameters with higher fructose intake (C<F10<F60). In addition, the F60 rats developed kidney hypertrophy, glomerular hypertension, cortical vasoconstriction, and arteriolopathy of preglomerular vessels. In conclusion, fructose-induced metabolic syndrome is associated with renal disturbances characterized by renal hypertrophy, arteriolopathy, glomerular hypertension, and cortical vasoconstriction. These changes are best observed in rats administered high doses (60% diet) of fructose.