Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5.

Abstract

Increased dietary fructose in rodents recapitulates many aspects of the Metabolic Syndrome with hypertension, insulin resistance and dyslipidemia. Here we show that fructose increased jejunal NaCl and water absorption which was significantly decreased in mice whose apical chloride/base exchanger Slc26a6 (PAT1, CFEX) was knocked out. Increased dietary… (More)
DOI: 10.1038/ki.2008.184

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