Fructose and tagatose protect against oxidative cell injury by iron chelation.

@article{Valeri1997FructoseAT,
  title={Fructose and tagatose protect against oxidative cell injury by iron chelation.},
  author={Franco Mosca Andrea Valeri and Franziska Boess and Antje Wolf and Christian G{\"o}ldlin and Urs Alex Boelsterli},
  journal={Free radical biology & medicine},
  year={1997},
  volume={22 1-2},
  pages={257-68}
}
To further investigate the mechanism by which fructose affords protection against oxidative cell injury, cultured rat hepatocytes were exposed to cocaine (300 microM) or nitrofurantoin (400 microM). Both drugs elicited massively increased lactate dehydrogenase release. The addition of the ketohexoses D-fructose (metabolized via glycolysis) or D-tagatose (poor glycolytic substrate) significantly attenuated cocaine- and nitrofurantoin-induced cell injury, although both fructose and tagatose… CONTINUE READING

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