Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes.

@article{Hue1993Fructose2A,
  title={Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes.},
  author={Louis Hue and G. G. Rousseau},
  journal={Advances in enzyme regulation},
  year={1993},
  volume={33},
  pages={97-110}
}
Tumor and proliferating cells maintain a high glycolytic rate even under aerobic conditions. The discovery of fructose 2,6-bisphosphate, a potent stimulator of glycolysis, has prompted a re-investigation of this phenomenon. Rat hepatoma cells and fibroblasts stimulated by mitogens or transformed by the Rous sarcoma virus carrying the v-src oncogene were used as models. The results indicate that in established lines of hepatoma cells the biochemical properties of the bifunctional enzyme, PFK-2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…