Fructose 1,6-bisphosphate prevented endotoxemia, macrophage activation, and liver injury induced by D-galactosamine in rats.

@article{Cuesta2006Fructose1P,
  title={Fructose 1,6-bisphosphate prevented endotoxemia, macrophage activation, and liver injury induced by D-galactosamine in rats.},
  author={Eduardo Huedo Cuesta and Jordi Boada and Roser Calafell and Jos{\'e} Carlos Perales and Teresa Sandoval Roig and J. F. Veles Bermudez},
  journal={Critical care medicine},
  year={2006},
  volume={34 3},
  pages={
          807-14
        }
}
OBJECTIVE Fructose 1,6-bisphosphate (F1,6BP) protects organs against a wide range of challenges involving inflammation. We hypothesized that the primary action of F1,6BP is to prevent macrophage activation and cytokine release. Our aim was to determine the tissue and cellular targets for this bisphosphorylated sugar and to provide new insights into its mechanisms of action. DESIGN Prospective, controlled laboratory study. SETTING Animal resource facilities and research laboratory… CONTINUE READING
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