Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress.

@article{Vexler2003Fructose16bisphosphatePI,
  title={Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress.},
  author={Zinaida S. Vexler and Arthur Wong and Carla Francisco and Catherine G Manabat and Stephan Christen and Martin George T{\"a}uber and D M Ferriero and George Gregory},
  journal={Brain research},
  year={2003},
  volume={960 1-2},
  pages={90-8}
}
Fructose-1,6-bisphosphate (FBP), an endogenous intermediate of glycolysis, protects the brain against ischemia-reperfusion injury. The mechanisms of FBP protection after cerebral ischemia are not well understood. The current study was undertaken to determine whether FBP protects primary neurons against hypoxia and oxidative stress by preserving reduced glutathione (GSH). Cultures of pure cortical neurons were subjected to oxygen deprivation, a donor of nitric oxide and superoxide radicals (3… CONTINUE READING
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