Fructose-1,6-bisphosphate preserves adenosine triphosphate but not intracellular pH during hypoxia in respiring neonatal rat brain slices.

@article{Espanol1998Fructose16bisphosphatePA,
  title={Fructose-1,6-bisphosphate preserves adenosine triphosphate but not intracellular pH during hypoxia in respiring neonatal rat brain slices.},
  author={Maryceline T. Espanol and Lawrence Litt and Kyoko Hasegawa and Leii H. Chang and Jr. MacDonald and M. D. George Gregory and Thomas Ll. James and Pak Hei Chan},
  journal={Anesthesiology},
  year={1998},
  volume={88 2},
  pages={
          461-72
        }
}
BACKGROUND Fructose-1,6-bisphosphate (FBP) sometimes provides substantial cerebral protection during hypoxia or ischemia. 31P/1H nuclear magnetic resonance spectroscopy of cerebrocortical slices was used to study the effects of FBP on hypoxia-induced metabolic changes. In addition, 13C-labeled glucose was administered and 13C nuclear magnetic resonance spectroscopy was used to search for FBP-induced modulations in glycolysis and the pentose-phosphate pathway. METHODS In each experiment, 80… CONTINUE READING
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