Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.

@article{Zhang2008Frs2alphadeficiencyIC,
  title={Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.},
  author={Jue Zhang and Yongshun Lin and Y Jonathan Zhang and Yongsheng Lan and Chunhong Lin and Anne M. Moon and Robert J. Schwartz and James F. Martin and Fen Wang},
  journal={Development},
  year={2008},
  volume={135 21},
  pages={3611-22}
}
The cardiac outflow tract (OFT) is a developmentally complex structure derived from multiple lineages and is often defective in human congenital anomalies. Although emerging evidence shows that fibroblast growth factor (FGF) is essential for OFT development, the downstream pathways mediating FGF signaling in cardiac progenitors remain poorly understood. Here, we report that FRS2alpha (FRS2), an adaptor protein that links FGF receptor kinases to multiple signaling pathways, mediates crucial… CONTINUE READING

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