Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

Abstract

Mutations in the progranulin (PGRN) gene have recently been identified in families with frontotemporal lobar degeneration and ubiquitin-positive brain inclusions linked to chromosome 17q21. We have previously described a Swedish family displaying frontotemporal dementia with rapid progression and linkage to chromosome 17q21. In this study, we performed an… (More)
DOI: 10.1007/s10048-008-0155-z

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