Frontostriatal deficits in unipolar major depression.

  title={Frontostriatal deficits in unipolar major depression.},
  author={Mark A. Rogers and John L. Bradshaw and Christos Pantelis and James G. Phillips},
  journal={Brain research bulletin},
  volume={47 4},
Recent accounts of major depression have tended to focus on dysfunction of frontothalamic-striatal reentrant circuits as a possible source of the disorder. Evidence of frontostriatal involvement in unipolar major depression from lesion and neuropsychological studies, and functional and structural imaging studies is examined. The high incidence of depressive symptomatology following left frontal and basal ganglia lesions implicate these as possible sites of dysfunction. Neuropsychological… CONTINUE READING
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