Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective Disorder

  title={Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective Disorder},
  author={Vibe G. Frokjaer and Erik Lykke Mortensen and Finn {\AA}rup Nielsen and Steven Haugbol and Lars H. Pinborg and Karen H. Adams and Claus Svarer and Steen Gregers Hasselbalch and Soeren Holm and Olaf Bjarne Paulson and Gitte Moos Knudsen},
  journal={Biological Psychiatry},
Neuroticism and serotonin 5-HT1A receptors in healthy subjects
Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding
The data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT2A receptor binding, pointing at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders.
Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females
It is found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality, which suggests that contribution of thalamus and striatum serotonin transporter to the risk of affective disorders depends on sex.
Dorsal prefrontal cortical serotonin 2A receptor binding indices are differentially related to individual scores on harm avoidance
Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits
A new continuum describing the relationship between personality and MAOA is proposed: deliberate/thoughtful contrasting aggressive/impulsive, and higher MAOA binding is associated with an adaptive personality facet.
Gender, personality, and serotonin-2A receptor binding in healthy subjects
No evidence for a role of the serotonin 4 receptor in five-factor personality traits: A positron emission tomography brain study
The findings indicate that NEO personality traits and 5-HT4R are not related in healthy participants and suggest that5-HT tone per se is not directly implicated in normal personality traits.


In Vivo Serotonin 5HT2A Receptor Binding and Personality Traits in Healthy Subjects: A Positron Emission Tomography Study
These results support the concept that the variability of PET data may be explained by neurochemical differences related to the prevalence of specific personality traits, and indicate the existence of a relationship between behavioral and neurobiological factors.
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
These results help to define specific personality features reproducibly associated with 5-HTTLPR genotype, enhancing the attractiveness of the five-factor personality model in genetic research on complex behavioral dimensions.
Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association
The present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits and the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R.
Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers.
The inverse relationship between 5-HT(1A) receptor binding potential and anxiety is consistent with animal models that have shown higher anxiety in mice lacking 5- HT( 1A) receptors and clinical trial data that have demonstrated antianxiety properties of partial 5-hydroxytryptophan agonists.
Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression.
The probability that stress-related cognitive vulnerabilities for depression result in symptom formation may be moderated by a neurobiologic phenotype characterized by altered processing of negative emotions associated with variation in 5-HTTLPR.
Prefrontal cortex 5-HT2 receptors in depression: an [18F]setoperone PET imaging study.
The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts, but this negative finding does not rule out the possibility that there is a role for 5- HT2 receptors in treatment or that 5-ht2 receptors are increased in highly suicidal states.