Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder☆

@inproceedings{Naaijen2017FrontostriatalGI,
  title={Fronto-striatal glutamate in children with Tourette's disorder and attention-deficit/hyperactivity disorder☆},
  author={Jilly Naaijen and Natalie J. Forde and David J. Lythgoe and Sophie E. A. Akkermans and Thaira J.C. Openneer and A M Dietrich and M. P. Zwiers and Pieter J. Hoekstra and Jan K. Buitelaar},
  booktitle={NeuroImage: Clinical},
  year={2017}
}
OBJECTIVE Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies. METHOD We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n… CONTINUE READING

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