Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia

@article{OCallaghan2013FrontostriatalAC,
  title={Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia},
  author={Claire O'Callaghan and Sharon L Naismith and John R. Hodges and Simon J G Lewis and Michael Hornberger},
  journal={Cortex},
  year={2013},
  volume={49},
  pages={1833-1843}
}
INTRODUCTION Impulsive behaviours commonly manifest in treated Parkinson's disease (PD) patients, and, are typically viewed as sequelae of dopaminergic therapy. However, recent evidence shows that impulsivity in those patients may not only depend on medication status. Instead, there is the suggestion that dopaminergic therapy interacts with existing neuroanatomical and/or neurochemical abnormalities, to produce impulsive behaviour in certain vulnerable patients. METHODS In this study, we… CONTINUE READING

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