Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway

@article{Dery2004FrontlineIO,
  title={Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway},
  author={René E. Déry and Marina Ulanova and Lakshmi Puttagunta and Grant R. Stenton and Deborah James and Shaheed Merani and Ronald D. Mathison and J. S. Davison and A Dean Befus},
  journal={European Journal of Immunology},
  year={2004},
  volume={34}
}
Interactions between the neuro‐endocrine system and immune system help maintain health. One interaction involves the superior cervical ganglia (SCG), which regulate the prohormone submandibular rat 1 (SMR1) produced by the submandibular gland (SMG). A peptide derived from SMR1, feG, has anti‐inflammatory activity, and modification to D‐isomer feG enhances bioactivity. We tested feG as a therapeutic agent for airways inflammation, using rats sensitized by OVA or Nippostrongylus brasiliensis (Nb… 
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37 Citations
Highly Influential Citations
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37 Citations

The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils

FeG reduces the capacity of circulating neutrophils to generate intracellular ROS consequent to an allergic reaction by preventing the deregulation of PKCδ.

Chronic use of the immunomodulating tripeptide feG-COOH in experimental feline asthma.

Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice

In brief, recombinant allergen Der f 2 can strengthen the function of hypothalamus-pituitary-adrenal (HPA) axis, affect the balance of Th1 and Th2 cytokines, and reduce pulmonary inflammation in asthmatic mice.

Prevention and amelioration of rodent endotoxin-induced lung injury with administration of a novel therapeutic tripeptide feG.

Tripeptide feG prevents and ameliorates acute pancreatitis-associated acute lung injury in a rodent model.

FeG reduced leukocyte infiltration, ameliorated the severity of inflammatory damage, and restored lung function when administered either prophylactically or therapeutically in a two-hit rat model of acute pancreatitis plus intratracheal lipopolysaccharide.

Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects

The only post-exposure measure that is effective against pulmonary ricinosis at clinically relevant time-points following intoxication in pre-clinical studies is passive immunization with anti-ricin neutralizing antibodies, which depends on antibody affinity and the time of treatment initiation within a limited therapeutic time window.

Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein

The term "Immune Selective Anti-Inflammatory Derivatives" (ImSAIDs) is proposed for salivary-derived peptides to distinguish this class of agents from corticosteroids and nonsteroidal anti-inflammatory drugs.

The tripeptide feG inhibits leukocyte adhesion

When administered in vivo, feG prevents inflammation-induced reductions in cell adhesion, as well as restoring its inhibitory effect in vitro, and appears to involve actions on αMβ2 integrin, with a possible interaction with the low affinity FcγRIII receptor (CD16).

A novel biomarker associated with distress in humans: calcium-binding protein, spermatid-specific 1 (CABS1).

  • T. RitzD. Rosenfield A. Befus
  • Psychology, Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2017
Calcium-binding protein spermatid-specific 1 (CABS1) is expressed in the human submandibular gland and has an anti-inflammatory motif similar to that in sub mandibular rat 1 in rats, which is readily detected in human saliva and is associated with psychological and physiological indicators of stress.

Role of cellular effectors in the emergence of ventilation defects during allergic bronchoconstriction.

The findings suggest that allergic airway inflammation is locally heterogeneous and is topographically associated with the local emergence of VDs following allergen challenge.

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