Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway

@article{Dry2004FrontlineIO,
  title={Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway},
  author={R. D{\'e}ry and M. Ulanova and L. Puttagunta and G. Stenton and D. James and S. Merani and R. Mathison and J. Davison and A. Befus},
  journal={European Journal of Immunology},
  year={2004},
  volume={34}
}
Interactions between the neuro‐endocrine system and immune system help maintain health. One interaction involves the superior cervical ganglia (SCG), which regulate the prohormone submandibular rat 1 (SMR1) produced by the submandibular gland (SMG). A peptide derived from SMR1, feG, has anti‐inflammatory activity, and modification to D‐isomer feG enhances bioactivity. We tested feG as a therapeutic agent for airways inflammation, using rats sensitized by OVA or Nippostrongylus brasiliensis (Nb… Expand
View on Wiley
ncbi.nlm.nih.gov
36 Citations
Highly Influential Citations
2
Background Citations
17
Methods Citations
5

36 Citations

Citation Type

Citation Type

The tripeptide feG regulates the production of intracellular reactive oxygen species by neutrophils
  • 13
feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma
  • 12
Chronic use of the immunomodulating tripeptide feG-COOH in experimental feline asthma.
  • 16
  • Highly Influenced
Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice
  • 3
  • PDF
Prevention and amelioration of rodent endotoxin-induced lung injury with administration of a novel therapeutic tripeptide feG.
  • 4
Tripeptide feG prevents and ameliorates acute pancreatitis-associated acute lung injury in a rodent model.
  • 8
Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects
  • 29
  • PDF
The tripeptide analog feG ameliorates severity of acute pancreatitis in a caerulein mouse model.
  • 23
  • PDF
Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein
  • 29
EGF receptor activation during allergic sensitization affects IL‐6‐induced T‐cell influx to airways in a rat model of asthma
  • 21
...
1
2
3
4
...

References

SHOWING 1-10 OF 38 REFERENCES
Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase1
  • 124
  • PDF
Submandibular gland peptide‐T (SGP‐T): Modulation of endotoxic and anaphylactic shock
  • 10
Marked antiinflammatory effects of decentralization of the superior cervical ganglia
  • 44
  • PDF
Regulation of leukocyte adhesion to heart by the tripeptides feG and feG(NH2).
  • 18
Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic brown-Norway rats.
  • 62
Attenuation of intestinal and cardiovascular anaphylaxis by the salivary gland tripeptide FEG and its d-isomeric analog feG
  • 31
Role for the submandibular gland in modulating pulmonary inflammation following induction of systemic anaphylaxis
  • 30
Airway hyperresponsiveness, elevation of serum-specific IgE and activation of T cells following allergen exposure in sensitized Brown-Norway rats.
  • 57
Submandibular Gland Peptide-T (SGP-T) Inhibits Intestinal Anaphylaxis
  • 11
Role of intercellular adhesion molecule-1 in antigen-induced lung inflammation in brown Norway rats.
  • 14
...
1
2
3
4
...