Frontal-striatal dysfunction during planning in obsessive-compulsive disorder.

  title={Frontal-striatal dysfunction during planning in obsessive-compulsive disorder.},
  author={Odile A. van den Heuvel and Dick J. Veltman and Henk J. Groenewegen and Danielle C. Cath and Anton J. L. M. van Balkom and Julie van Hartskamp and Frederik Barkhof and Richard van Dyck},
  journal={Archives of general psychiatry},
  volume={62 3},
BACKGROUND Dysfunction of frontal-striatal, particularly orbitofrontal-striatal, circuitry has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD), characterized by obsessions, ritualistic behavior, anxiety, and specific cognitive impairments. In addition, neuropsychological studies in OCD have reported impairments in visuospatial tasks and executive functions, such as planning. OBJECTIVE To determine whether dorsal prefrontal-striatal dysfunction mediates planning… CONTINUE READING
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