Frontal signal hyperintensities in mania in old age.

  title={Frontal signal hyperintensities in mania in old age.},
  author={J de Asis and Blaine S. Greenwald and George S. Alexopoulos and Dimitris N. Kiosses and Manzar Ashtari and Moonseong Heo and Robert H. Young},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  volume={14 7},
OBJECTIVE Signal hyperintensities (SH) on magnetic resonance (MR) imaging have been associated with increased age and with mood disorders. Frontal and subcortical neuropathology has been implicated in the pathophysiology of mania and bipolar disorders. The authors assessed frontal and subcortical SH in elderly bipolar manic patients and the comparison group, and hypothesized that SH scores would be greater in the patient group. METHOD MR imaging was performed in patients aged > or = 60 years… CONTINUE READING

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