Frontal lobe abnormalities on MRS correlate with poor letter fluency in ALS.

@article{Quinn2012FrontalLA,
  title={Frontal lobe abnormalities on MRS correlate with poor letter fluency in ALS.},
  author={Colin C Quinn and L. B. Elman and L. F. McCluskey and Katelin Hoskins and Chafic Y. Karam and John H. Woo and Harish Poptani and Sumei Wang and Sanjeev Chawla and Scott E Kasner and Murray Grossman},
  journal={Neurology},
  year={2012},
  volume={79 6},
  pages={
          583-8
        }
}
OBJECTIVE To examine whether frontal lobe abnormalities on magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis (ALS) correlate with poor letter fluency (LF). METHODS Twenty-five patients with ALS (20 with definite, probable, or possible ALS and 5 with progressive muscular atrophy) performed an LF task, involving F word generation in 1 minute, and underwent MRS. Comparisons were made between patients with ALS with impaired LF and unimpaired LF based on an empirically derived… CONTINUE READING
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