Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.

@article{BimonteNelson2003FrontalCB,
  title={Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.},
  author={Heather A. Bimonte-Nelson and Christopher L Hunter and Matthew E. Nelson and Ann-Charlotte E. Granholm},
  journal={Behavioural brain research},
  year={2003},
  volume={139 1-2},
  pages={47-57}
}
Individuals with Down syndrome (DS) develop most neuropathological hallmarks of Alzheimer's disease early in life, including loss of cholinergic markers in the basal forebrain. Ts65Dn mice, an animal model of DS, perform poorly on tasks requiring spatial memory and also exhibit basal forebrain pathology beginning around 6 months of age. We evaluated memory as well as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) protein levels in basal forebrain, frontal cortex… CONTINUE READING
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