Frontal bone healing is sensitive to Wnt signaling inhibition via lentiviral encoded β-catenin shRNA.

@article{Zhang2018FrontalBH,
  title={Frontal bone healing is sensitive to Wnt signaling inhibition via lentiviral encoded β-catenin shRNA.},
  author={Lei Zhang and Leslie Le Chang and Jiajia Xu and Carolyn A. Meyers and Noah Yan and Erin Zou and Catherine Ding and K -L.H. Ting and Chia Soo and Shen Pang and Aaron W. James},
  journal={Tissue engineering. Part A},
  year={2018}
}
The Wnt/β-catenin signaling pathway plays an integral role in skeletal biology, spanning from embryonic skeletal patterning, through bone maintenance and bone repair. Most experimental methods to antagonize Wnt signaling in vivo are either systemic or transient, including genetic approaches, use of small molecule inhibitors, or neutralizing antibodies. We… CONTINUE READING