Front and back by Rho and Rac

  title={Front and back by Rho and Rac},
  author={Keith Burridge and Renee Doughman},
  journal={Nature Cell Biology},
The RhoGTPases Rac and Rho are important for orchestrating cytoskeletal dynamics during cell migration and crosstalk to antagonize each others' activities. The discovery of a Rac GTPase activating protein (GAP) that is regulated by Rho and Rho kinase (ROCK) provides a new basis for this crosstalk. 

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