• Corpus ID: 86228769

Frondanol® A5: A novel nutrapreventive and therapeutic agent derived from sea cucumber showing promising antiproliferative, antiinflammatory and antiangiogenic activities.

@inproceedings{Collin2006FrondanolAA,
  title={Frondanol{\textregistered} A5: A novel nutrapreventive and therapeutic agent derived from sea cucumber showing promising antiproliferative, antiinflammatory and antiangiogenic activities.},
  author={Peter D. Collin and Thomas E Adrian and Alexandra B. Roginsky and Robert A Newman and Carl Woodward and Rajendra G Mehta and Zi-Rong Ding and Boris V. Pinegin and Vladimir I. Kalinin and Dimitry Aminin and S. A. Avilov and Valentin A Stonik and Sheela Sharma and Irving Johnson},
  year={2006}
}
Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Nov 12-15, 2006 A80 We continue to explore extracts and pure molecules derived from the holothurian (sea cucumber) Cucumaria frondosa . With support from the NCI's RAPID Program, we investigated Frondanol® A5, for indications of therapeutic and preventive effects against cancer. We have shown that Frondanol A5 and its glycoside components inhibit growth of pancreatic cancer cells through induction of apoptosis… 
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Chemopreventive Effects of Frondanol A5, a Cucumaria frondosa Extract, against Rat Colon Carcinogenesis and Inhibition of Human Colon Cancer Cell Growth
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Overall, Frondanol A5 exhibits potential chemopreventive properties for colon carcinogenesis, which suggests further development of this sea cucumber extract.
Current Knowledge on the Biology, Ecology, and Commercial Exploitation of the Sea Cucumber Cucumaria frondosa
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This comprehensive synthesis, including 10 theses, 197 scientific papers and 47 reports, aims to provide a framework for future research by highlighting areas of concern for academic studies, fishery management, and aquaculture of cold-water sea cucumber species.