From wortmannin and LY 294002 : the path towards clinical candidates for PI 3 K inhibition

Abstract

In contrast with cytotoxic agents that do not differentiate between normal proliferating and tumour cells, targeted therapies primarily exert their actions in cancer cells. Initiation and maintenance of tumours are due to genetic alterations in specific loci. The identification of the genes in which these alterations occur has opened new opportunities for… (More)

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