From vestigial to vestigial-like: the Drosophila gene that has taken wing

@article{Simon2016FromVT,
  title={From vestigial to vestigial-like: the Drosophila gene that has taken wing},
  author={Emilie Simon and Corinne Faucheux and Alain Zider and Nadine Th{\'e}z{\'e} and Pierre Thi{\'e}baud},
  journal={Development Genes and Evolution},
  year={2016},
  volume={226},
  pages={297-315}
}
The members of the vestigial-like gene family have been identified as homologs of the Drosophila vestigial, which is essential to wing formation. All members of the family are characterized by the presence of the TONDU domain, a highly conserved sequence that mediates their interaction with the transcription factors of the TEAD family. Mammals possess four vestigial-like genes that can be subdivided into two classes, depending on the number of Tondu domains present. While vestigial proteins… Expand
The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
TLDR
It is shown that Vestigial is extensively post-translationally modified and at least one of these modifications is required for proper function during development and differences in the ability to rescue the wing and muscle phenotypes associated with a null vestigial allele are shown. Expand
Multiple Roles of Vestigial-Like Family Members in Tumor Development
TLDR
The recently identified multiple roles of VGLL members in tumor development are summarized and important and novel insights regarding tumorigenesis are provided. Expand
Vestigial-like 3 is a novel Ets1 interacting partner and regulates trigeminal nerve formation and cranial neural crest migration
TLDR
Vgll3 is a new partner of Ets1 and regulates trigeminal nerve formation and cranial neural crest cell migration and is a potent activator of pax3, zic1, Wnt and FGF, which are important for brain patterning and Neural crest cell formation. Expand
A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors
TLDR
Surprisingly, the TEAD-binding domain of Drosophila Vg and of human VGLL2 is more complex and contains an additional structural element, an Ω-loop, that contributes to TEAD binding and in vivo function, illustrating how structural and functional constraints can guide the evolution of transcriptional cofactors to preserve their ability to compete with other cofactor for binding to transcription factors. Expand
A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors
TLDR
Surprisingly, the TEAD-binding domain of Drosophila Vg and of human VGLL2 is more complex and contains an additional structural element, an Ω-loop, that contributes to TEAD binding. Expand
Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications
TLDR
It is shown that the full-length VGLL4/Tgi proteins behave as intrinsically disordered proteins, revealing that the length of the region between the two binding sites has little effect on the interaction with TEAD4/Sd. Expand
Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway
TLDR
Results suggest that VGLL3 together with TEADs promotes cell proliferation by activating the Hippo pathway through LATS2 and AMOTL2, leading to YAP/TAZ inactivation. Expand
Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers
TLDR
It is found that vestigial (Nlvg), a key wing-patterning gene, is selectively and temporally regulated by the IIS–FoxO signaling cascade during the wing-morph decision stage (fifth-instar stage) of Nilaparvata lugens. Expand
Vestigial-like 2 contributes to normal muscle fiber type distribution in mice
TLDR
Results suggest that Vgll2 may be both directly and indirectly involved in the programing of slow muscle fibers through the formation of the V gll2-TEAD complex. Expand
Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors
TLDR
Two new TEAD interactors are identified: FAM181A and FAM181B, both of which possess the LxxLF motif, found in YAP/TAZ, which suggests a potential new involvement of the TEAD transcription factors in the development of this tissue. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 114 REFERENCES
Vestigial like gene family expression in Xenopus: common and divergent features with other vertebrates.
TLDR
Four Xenopus vgll genes have unique/complex expression profiles and they are differently expressed during embryogenesis, displaying distinct responses to the major signaling pathways that orchestrate pattern-formation during early development. Expand
The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila.
TLDR
It is shown that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes involved in wing morphogenesis. Expand
Two different vestigial like 4 genes are differentially expressed during Xenopus laevis development.
TLDR
It is demonstrated that Xenopus has two orthologues of the vgll4 gene, v gll4 and vgLL4l with differential expression in Xenopus embryos and they may well have different roles during development. Expand
Molecular organization of the vestigial region in Drosophila melanogaster.
TLDR
The vestigial (vg) locus of Drosophila melanogaster is involved in wing margin development and deficiency analysis and molecular mapping identified sequences, spanning approximately 20 kb of DNA within the larger region, which are necessary for vg function. Expand
The functional organization of the vestigial locus in Drosophila melanogaster
TLDR
The identification and characterization of a developmentally regulated 3.8 kb vg transcript which is spliced from exons distributed throughout the essential interval defined above and indicates that sequences within a vg intron are essential for normal wing and haltere development. Expand
Specific interactions between vestigial and scalloped are required to promote wing tissue proliferation in Drosophila melanogaster
TLDR
It is demonstrated that ptc-GAL4-driven expression of vg induces both expressions of the endogenous vg and sd genes and that the two Vg and Sd proteins have to be produced together to promote wing proliferation. Expand
Comparative Expression Pattern of Two Vestigial-Like 2 Genes in Zebrafish
TLDR
Investigating the role of vestigial-like 2 (vgll2) in zebrafish muscle development and genetic regulation of vgll2 genes was analysed using smu mutants and data revealed that both genes are regulated via the Hedgehog signaling pathway. Expand
TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.
TLDR
It is found that the transcriptional activity of the Vg-Sd heterodimer is negatively regulated at the AP and DV boundary of the wing disc, and it is proposed that TDU is a specific coactivator for the mammalian TEFs. Expand
The vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila.
TLDR
A general role for Wingless during development is proposed in which it stabilizes cell fate decisions that have been implemented by other molecules. Expand
The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila.
TLDR
Observations indicate that the scalloped (sd) gene encodes a transcription factor that functions in the regulation of cell-specific gene expression during Drosophila development, particularly in the differentiation of the nervous system. Expand
...
1
2
3
4
5
...