From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Using unbiased transcript profiling in an ALS mouse model, we identified a role for the co-stimulatory pathway, a key regulator of immune responses. Furthermore, we observed that this pathway is upregulated in the blood of 56% of… (More)
DOI: 10.1038/ng.557

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Cite this paper

@article{Lincecum2010FromTA, title={From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis}, author={John M. Lincecum and Fernando Emmanuel Gonçalves Vieira and Monica Z. Wang and Kenneth L. Thompson and Gerald S De Zutter and Joshua D. Kidd and Andrew Moreno and Ricardo Sanchez and Isarelis J Carrion and Beth A. Levine and Bashar M Al-Nakhala and Shawn Sullivan and A. S. Gill and Steven R. Perrin}, journal={Nature Genetics}, year={2010}, volume={42}, pages={392-399} }