From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug

@article{Lock2004FromTP,
  title={From toxicological problem to therapeutic use: The discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC), its toxicology and development as a drug},
  author={E. Lock and M. K. Ellis and P. Gaskin and M. Robinson and T. Auton and W. M. Provan and L. Smith and M. P. Prisbylla and L. Mutter and D. Lee},
  journal={Journal of Inherited Metabolic Disease},
  year={2004},
  volume={21},
  pages={498-506}
}
  • E. Lock, M. K. Ellis, +7 authors D. Lee
  • Published 2004
  • Medicine, Biology
  • Journal of Inherited Metabolic Disease
  • NTBC is a triketone with herbicidal activity that has been shown to have a novel mode of action by inhibiting the enzyme 4-hydroxyphenylpyruvate dioxygenase in plants. Early studies on the toxicity of this compound found that rats treated with NTBC developed corneal lesions. Investigations aimed at understanding the mechanistic basis for the ocular toxicity discovered that the rats developed tyrosinaemia and excreted large amounts of 4-hydroxyphenylpyruvate and 4-hydroxyphenyllactate, owing to… CONTINUE READING
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    Tyrosinaemia type I and NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione)
    • 212
    Triketone toxicity
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    References

    SHOWING 1-10 OF 57 REFERENCES