From toxic precursors to safe drugs. Mechanisms and relevance of idiosyncratic drug reactions.

@article{Petersen2002FromTP,
  title={From toxic precursors to safe drugs. Mechanisms and relevance of idiosyncratic drug reactions.},
  author={Kenneth Lee Petersen},
  journal={Arzneimittel-Forschung},
  year={2002},
  volume={52 6},
  pages={
          423-9
        }
}
In adverse drug reactions, effects accounted for by the pharmacological profile of the drug may be distinguished from sometimes bizarre, unpredictable events ("idiosyncrasies"). In the majority of cases, the latter are due to reactive intermediates formed by members of the cytochrome P450 family of enzymes. These products are usually formed at very low quantities. However, genetic disposition (e.g. by enhanced expression of the catalyzing enzyme or failure of protective factors such as… CONTINUE READING
BETA