From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.

@article{Drab1997FromTE,
  title={From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.},
  author={M Drab and Hermann Haller and Rostislav Bychkov and Bettina Erdmann and Carsten Lindschau and Hannelore Haase and Ingo Morano and Friedrich C. Luft and Anna M. Wobus},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1997},
  volume={11 11},
  pages={905-15}
}
Vascular smooth muscle cell (VSMC) differentiation is important in understanding vascular disease; however, no in vitro model is available. Totipotent mouse embryonic stem (ES) cells were used to establish such a model. To test whether the ES cell-derived smooth muscle cells expressed VSMC-specific properties, the differentiated cells were characterized by 1) morphological analysis, 2) gene expression, 3) immunostaining for VSMC-specific proteins, 4) expression of characteristic VSMC ion… CONTINUE READING
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