From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.

@article{Capell2009FromTR,
  title={From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.},
  author={Brian C. Capell and Brook E Tlougan and Seth J Orlow},
  journal={The Journal of investigative dermatology},
  year={2009},
  volume={129 10},
  pages={2340-50}
}
Despite their rarity, diseases of premature aging, or "progeroid" syndromes, have provided important insights into basic mechanisms that may underlie cancer and normal aging. In this review, we highlight these recent developments in Hutchinson-Gilford progeria syndrome (HGPS), Werner syndrome, Bloom syndrome, Cockayne syndrome, trichothiodystrophy, ataxia-telangiectasia, Rothmund-Thomson syndrome, and xeroderma pigmentosum. Though they are caused by different mutations in various genes and… CONTINUE READING

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