From the pigments of the actinomycetes to third generation antitumor anthracyclines.

@article{Arcamone1998FromTP,
  title={From the pigments of the actinomycetes to third generation antitumor anthracyclines.},
  author={F M Arcamone},
  journal={Biochimie},
  year={1998},
  volume={80 3},
  pages={201-6}
}
After the assessment of the antitumor activity of the anthracycline pigments, the S peucetius group of metabolites was discovered and eventually doxorubicin, a major anticancer agent of established clinical usefulness was developed in the early seventies. A second generation of compounds followed, represented mainly by the better tolerated epirubicin and by the highly potent antileukemic drug, idarubicin. This was the result of a wide program of analog development that provided the basis for… CONTINUE READING

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