From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia.

@article{Oliveira2017FromTO,
  title={From the outside, from within: Biological and therapeutic relevance of signal transduction in T-cell acute lymphoblastic leukemia.},
  author={Mariana L V Oliveira and Padma Akkapeddi and Isabel Alcobia and Afonso Rocha Martins Almeida and Bruno A Cardoso and Rita Fragoso and Teresa L. Serafim and Jo{\~a}o T Barata},
  journal={Cellular signalling},
  year={2017},
  volume={38},
  pages={
          10-25
        }
}
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer that arises from clonal expansion of transformed T-cell precursors. In this review we summarize the current knowledge on the external stimuli and cell-intrinsic lesions that drive aberrant activation of pivotal, pro-tumoral intracellular signaling pathways in T-cell precursors, driving transformation, leukemia expansion, spread or resistance to therapy. In addition to their pathophysiological relevance, receptors… CONTINUE READING
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