From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics.

@article{Kirla2016FromTC,
  title={From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics.},
  author={Krishna Tulasi Kirla and Ksenia J. Groh and Andrea E Steuer and Michael Poetzsch and Rakesh Kumar Banote and Julita Stadnicka-Michalak and Rik I. L. Eggen and Kristin Schirmer and Thomas Kraemer},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016},
  volume={154 1},
  pages={183-193}
}
Zebrafish (Danio rerio) larvae have been suggested as vertebrate model to complement or even replace mammals for rapidly assessing behavioral effects of psychoactive drugs. Yet, divergent responses have been reported in mammals and fish despite the conservation of many drug targets. Cocaine, eg, acts as stimulant in mammals but no such response has been documented for zebrafish larvae. We hypothesized that differences in exposure routes (inhalation or injection in mammals vs waterborne in fish… CONTINUE READING
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