From the Cover: The dynamics of genomic-length DNA molecules in 100-nm channels.

  title={From the Cover: The dynamics of genomic-length DNA molecules in 100-nm channels.},
  author={Jonas O. Tegenfeldt and Christelle Prinz and Han Cao and Steven P Chou and Walter W. Reisner and Robert Riehn and Yan Mei Wang and Edward C. Cox and James C. Sturm and Pascal Silberzan and Robert H Austin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 30},
We show that genomic-length DNA molecules imaged in nanochannels have an extension along the channel that scales linearly with the contour length of the polymer, in agreement with the scaling arguments developed by de Gennes for self-avoiding confined polymers. This fundamental relationship allows us to measure directly the contour length of single DNA molecules confined in the channels, and the statistical analysis of the dynamics of the polymer in the nanochannel allows us to compute the SD… CONTINUE READING


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