From the Cover: Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier

@article{Yang2017FromTC,
  title={From the Cover: Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier},
  author={Liecheng Yang and Xiaoyan Zhong and Q. Li and X. Zhang and Yangyun Wang and K. Yang and L. Zhang},
  journal={Toxicological Sciences},
  year={2017},
  volume={156},
  pages={39–53}
}
  • Liecheng Yang, Xiaoyan Zhong, +4 authors L. Zhang
  • Published 2017
  • Chemistry, Medicine
  • Toxicological Sciences
  • Cationic amphiphilic drugs (CADs) are small molecules that can induce phospholipidosis (PLD), causing the intracellular accumulation of phospholipid in the lamellar bodies. Nanotechnology based drug delivery systems have been used widely, while it is unknown if drug-induced PLD (DIP) can be potentiated through drug retention by indigestible nanocarriers. Due to the high drug loading capacity of graphene, we investigated if PEGylated graphene oxide (PEG-GO) loaded with CAD could potentiate DIP… CONTINUE READING
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    References

    SHOWING 1-10 OF 74 REFERENCES
    Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs.
    • 1,215
    PEGylated graphene oxide for tumor-targeted delivery of paclitaxel.
    • 43
    • PDF
    Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy
    • 48
    • PDF
    PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
    • 2,754
    • PDF
    Tamoxifen loaded folic acid armed PEGylated magnetic nanoparticles for targeted imaging and therapy of cancer.
    • 69
    In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies.
    • 89
    • Highly Influential
    • PDF
    Preparation and functionalization of graphene nanocomposites for biomedical applications
    • 197
    • Highly Influential
    Pegylated Liposomal Doxorubicin: Metamorphosis of an Old Drug into a New Form of Chemotherapy
    • 475