From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.

@article{Wang2018FromTC,
  title={From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity.},
  author={Xue Wang and Lifeng Han and Gentao Li and Wei Peng and Xiumei Gao and Curtis D. Klaassen and Guanwei Fan and Youcai Zhang},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2018},
  volume={161 2},
  pages={
          321-334
        }
}
Mercury accumulates in kidneys and produces acute kidney injury. Semen cassiae (SC), a widely consumed tea and herbal medicine in Eastern Asia, has been reported to have protective effects on kidneys. In this study, SC extract was shown to almost abolish the histological alterations induced by mercuric chloride in rat kidneys. A total of 22 compounds were isolated from SC, and 1,7,8-methoxyl-2-hydroxyl-3-methyl-anthraquinone was detected in SC for the first time. Among the eight compounds… CONTINUE READING
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