From the Cover: Development and Application of a Dual Rat and Human AHR Activation Assay.

Abstract

Significant prolonged aryl hydrocarbon receptor (AHR) activation, classically exhibited following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent toxicities in pre-clinical species and man. Previous… (More)
DOI: 10.1093/toxsci/kfx188

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