From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

@article{Nault2016FromTC,
  title={From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.},
  author={Rance Nault and Kelly A Fader and Anna K. Kopec and Jack R. Harkema and Timothy R. Zacharewski and James P. Luyendyk},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016},
  volume={154 2},
  pages={381-391}
}
Emerging evidence supports a role for environmental chemical exposure in the pathology of non-alcoholic fatty liver disease (NAFLD), a disease process tightly linked to increased activity of the blood coagulation cascade. Exposure of C57BL/6 mice to the persistent environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) recapitulates features of the NAFLD spectrum, including steatosis, hepatic injury, inflammation, and fibrosis. We assessed coagulation cascade activation, and… CONTINUE READING
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