Corpus ID: 28737928

From sugar beet molasses to Lyphan. Integrated quality management from the raw material to the drug.

@article{Faurie1999FromSB,
  title={From sugar beet molasses to Lyphan. Integrated quality management from the raw material to the drug.},
  author={Robert Faurie and Gerhard Dr. Fries},
  journal={Advances in experimental medicine and biology},
  year={1999},
  volume={467},
  pages={
          443-52
        }
}
  • R. Faurie, G. Fries
  • Published 1999
  • Biology, Medicine
  • Advances in experimental medicine and biology
L-tryptophan is produced at the AMINO GmbH (Frellstedt, FRG) via biocatalytical condensation of the amino acid L-serine with indole. As a biocatalyst, tryptophan synthetase is used which is produced in high activities by a natural mutant Escherichia coli strain. The enzyme mechanism and specificity and the individual process-parameters for the biotransformation procedure are explained as well as the purification process of educts and products. This includes a detailed description of the quality… Expand
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