From structural biochemistry to expression profiling: neuroprotective activities of estrogen.

@article{Manthey2006FromSB,
  title={From structural biochemistry to expression profiling: neuroprotective activities of estrogen.},
  author={Dieter Manthey and Christian Behl},
  journal={Neuroscience},
  year={2006},
  volume={138 3},
  pages={845-50}
}
Estrogens are neuromodulatory and neuroprotective hormones. Chemically, estrogens are steroid compounds and unfold most of their activities through the activation of nuclear receptors that bind to specific target genes and control their transcription. Two subtypes of estrogen receptors are known (estrogen receptor alpha and estrogen receptor beta) and they are expressed throughout the body including the CNS and in particular the brain. We employed large scale DNA-chip-analysis to display the… CONTINUE READING

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