From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli.

@article{Thieffry1998FromSG,
  title={From specific gene regulation to genomic networks: a global analysis of transcriptional regulation in Escherichia coli.},
  author={Denis Thieffry and Araceli M. Huerta and Ernesto P{\'e}rez-Rueda and Julio Collado-Vides},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1998},
  volume={20 5},
  pages={433-40}
}
Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms. This paper presents a global characterization of the transcriptional regulation in Escherichia coli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing… CONTINUE READING