From solution to the gas phase: stepwise dehydration and kinetic trapping of substance P reveals the origin of peptide conformations.

@article{Silveira2013FromST,
  title={From solution to the gas phase: stepwise dehydration and kinetic trapping of substance P reveals the origin of peptide conformations.},
  author={Joshua A Silveira and Kyle L Fort and Doyong Kim and Kelly A. Servage and Nicholas A Pierson and David E. Clemmer and David H Russell},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 51},
  pages={19147-53}
}
Past experimental results and molecular dynamics simulations provide evidence that, under some conditions, electrospray ionization (ESI) of biomolecules produces ions that retain elements of solution phase structures. However, there is a dearth of information regarding the question raised by Breuker and McLafferty, "for how long, under what conditions, and to what extent, can solution structure be retained without solvent?" (Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 18145). Here, we use… CONTINUE READING

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