From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism.

@article{Lambein1994FromST,
  title={From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motorneurone disease neurolathyrism.},
  author={Fernand Lambein and Rabiul Haque and Jehangir K. Khan and Naod Kebede and Y H Kuo},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1994},
  volume={32 4},
  pages={
          461-6
        }
}
  • F. Lambein, R. Haque, +2 authors Y. Kuo
  • Published 1 April 1994
  • Biology, Medicine
  • Toxicon : official journal of the International Society on Toxinology
Zinc deficiency and oversupply of iron to the roots of grass pea (Lathyrus sativus) induce increases in the content of the neurotoxin beta-L-ODAP (3-oxalyl-L-2,3-diaminopropanoic acid) in the ripe seeds. The transport of zinc to the shoots is enhanced by the addition of beta-L-ODAP. The neurotoxin of L. sativus is proposed to function as a carrier molecule for zinc ions. Soils, depleted in micronutrients from flooding by monsoon rains (Indian subcontinent) or otherwise poor in available zinc… 
Implications of Zinc Fertilization for Ameliorating Toxicity (Neurotoxin) in Grasspea ( Lathyrus sativus )
Grasspea ( Lathyrus sativus ) is a protein-rich forage legume that contains a neurotoxin (beta-ODAP) that causes severe malformation of the body’s extremities when eaten in large quantities. Various
Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes
TLDR
The effect of L-β-ODAP was studied as compared to L-glutamate on the permeability of the blood-brain barrier (BBB), on the survival and functioning of neuronal and glial cells, and free amino acids were analyzed in urine of neurolathyrism patients.
Reduction of β-ODAP and IP6 contents in Lathyrus sativus L. seed by high hydrostatic pressure.
TLDR
It can be concluded that pressure, soaking and holding time as well as the grass pea seed accession/variety had great impact on molecular structure changes, enhancement of enzyme activity and reduction in β-ODAP and IP6 content.
Potentiation of neurotoxicity of Lathyrus sativus by manganese: Alterations in blood–brain barrier permeability
TLDR
The results suggest that Mn may potentiate the neurotoxicity of lathyrus/ODAP by altering the blood–brain barrier permeability and neurotoxicity studies were carried out in manganese- and LS-exposed animals.
Lathyrus sativus (grass pea) and its neurotoxin ODAP.
TLDR
Advances in understanding L. sativus from the perspective of its taxonomy, genetics, ecology, chemistry, nutrition, medicine, biology and for animal nutrition are addressed.
Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from Ethiopia.
TLDR
The amino acid metabolism of the neurolathyrism patients is disturbed by over-consumption of grass pea seeds, and the high concentrations of Cu found in the patient urine might indicate the involvement of trace elements in the aetiology of neurolATHyrism.
Tissue specific expression and in-silico characterization of a putative cysteine synthase gene from Lathyrus sativus L.
TLDR
A probable way towards the development of less toxic consumer-safe grass pea by down-regulation or deactivation of such gene/s (cysteine synthase) through genetic manipulations is offered.
Factors affecting β-ODAP content in Lathyrus sativus and their possible physiological mechanisms.
  • Cj Jiao, J. Jiang, +4 authors C.‐Y. Wang
  • Biology, Medicine
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
A neuroexcitatory non-protein amino acid, β-N-oxalyl-L-α,β-diaminopropionic acid (β-ODAP), present in the seeds of the hardy legume crop grass pea (Lathyrus sativus L.), was considered responsible
Neuroactive and other free amino acids in seed and young plants of Panax ginseng.
TLDR
Glutamine and arginine were the two major free proteinogenic amino acids in the ginseng plants and together they constituted over 50% of all the free amino acids detected in the root.
Metabolism of dietary ODAP in humans may be responsible for the low incidence of neurolathyrism.
TLDR
The low excretion of dietary ingested ODAP in humans is in sharp contrast to that seen in animals and indicates a metabolism or detoxification of ODAP which may be unique to humans and may explain the low incidence of neurolathyrism.
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References

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Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder.
TLDR
Most patients developed the disease in the epidemic of 1976/77, although new cases appear to have occurred with an estimated mean annual incidence of 1.7:10,000, making attempts to develop low-BOAA strains to prevent lathyrism increasingly important.
Facile isolation, from L. sativus seed, of the neurotoxin β-N-oxalyl-L-α, β-diaminopropionic acid as the copper complex and studies of the coordination chemistry of copper and zinc with the amino acid in aqueous solution
Abstract In the present paper we report studies of the precipitation of the copper complex of β-ODAP directly from seed extracts. We have also studied the aqueous chemistry of the amino acid with
Biosynthesis of the neurotoxin β-N-oxalyl-α,β-diaminopropionic acid in callus tissue of Lathyrus sativus
TLDR
The previous finding that BIA is the precursor for ODAP was confirmed and DAPRO may indeed be the short-lived intermediate in this pathway, and the incorporation of [ 14C ] into ODAP shows a concentration dependent inhibition.
Lathyrism: a neurotoxic disease.
TLDR
Current attention is focused on the glutamate analog, beta-(N)-oxalyl-amino-L-alanine acid (BOAA), which is present in those lathyrus species that induce spastic paraparesis and, in large doses, reportedly causes neuropathological changes similar to glutamate neurotoxicity.
Release of endogenous Zn2+ from brain tissue during activity
TLDR
It is demonstrated for the first time that Zn2+ is released into the extracellular space during excitation of hippocampal slices.
LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAA
TLDR
Primate feeding studies show that beta-N-oxalylamino-L-alanine (BOAA), a potent neuroexcitatory aminoacid in the chickling pea, induces corticospinal dysfunction similar to that seen in animals consuming a fortified diet of this legume.
Toxins in the seedlings of some varieties of grass pea (Lathyrus sativus).
The major toxin present in the dry seeds and seedlings of Lathyrus sativus is the neurotoxin 3-N-oxalyl-L-2,3-diaminopropanoic acid (beta-ODAP). The presence of one additional neurotoxin and an
Complexes of zinc, copper, and nickel with the nonprotein amino acid L-α-amino-β-methylaminopropionic acid: A naturally occurring neurotoxin
Abstract The non-protein amino acid L-α-amino-β-methylaminopropionic acid (L-MeDAP) causes motor neuron dysfunction in macaques. The amino acid is a potent chelator of divalent metal ions such as
β-isoxazolinone-alanine is involved in the biosynthesis of the neurotoxin β-N-oxalyl-l-α,β-diaminopropionic acid
Abstract The biosynthetic precursor of the neurotoxic amino acid α-β-oxalyl- l -α,β-diaminopropionic acid (ODAP) is β-(isoxazolin-5-on-2-yl)- l -alanine (BIA) a prominent metabolise only during the
Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus
An ultra-filtration method for separating free Zn from its bound form with macromolecules was used to study the effect of excitatory amino acids on dissociation of Zn in the soluble fraction of rat
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