From small fluctuations to large-scale phase separation: lateral organization in model membranes containing cholesterol.

@article{Veatch2007FromSF,
  title={From small fluctuations to large-scale phase separation: lateral organization in model membranes containing cholesterol.},
  author={Sarah L Veatch},
  journal={Seminars in cell & developmental biology},
  year={2007},
  volume={18 5},
  pages={
          573-82
        }
}
Macroscopic coexisting liquid phases are readily observed in certain model membranes containing cholesterol and at least two other lipid components. Recent fluorescence microscopy and deuterium NMR work indicates that submicron fluctuations are also found, in vesicles with near-critical lipid compositions. In principle, the magnitude of critical fluctuations can be controlled by changing temperature, or through other means of shifting the phase boundary such as including impurities or cross… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Visualizing monolayers with a water-soluble fluorophore to quantify adsorption, desorption, and the double layer.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND & METHODS

Influence of Molecular Coherence on Surface Viscosity

  • Langmuir : the ACS journal of surfaces and colloids
  • 2014

Effect of cholesterol nanodomains on monolayer morphology and dynamics.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 133 REFERENCES

Critical fluctuations in domain-forming lipid mixtures.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2007
VIEW 10 EXCERPTS

Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Lipid rafts reconstituted in model membranes.

  • Biophysical journal
  • 2001
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL