From skeletal muscle to cancer: insights learned elucidating the function of tropomyosin.

@article{Choi2012FromSM,
  title={From skeletal muscle to cancer: insights learned elucidating the function of tropomyosin.},
  author={Cheolwon Choi and Dayoung Kim and Sabina Kim and Sukyeong Jeong and Eunsol Song and D. M. Helfman},
  journal={Journal of structural biology},
  year={2012},
  volume={177 1},
  pages={63-9}
}
The tropomyosins (Tms) are a family of actin filament binding proteins that possess a simple dimeric α-helical coiled-coil structure along their entire length. Our knowledge of Tm structure and function has greatly expanded since they were first discovered in skeletal muscle almost 65 years ago. In multicellular organisms they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its significance to actin… CONTINUE READING

From This Paper

Topics from this paper.
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…