From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

@article{Trevaskis2015FromST,
  title={From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity},
  author={Natalie L Trevaskis and Lisa M Kaminskas and Christopher J. H. Porter},
  journal={Nature Reviews Drug Discovery},
  year={2015},
  volume={14},
  pages={781-803}
}
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of metastasis, and recent studies have suggested intrinsic links between lymphatic function, lipid deposition, obesity and atherosclerosis. Advances in the current understanding of the role of the lymphatics in pathological change and immunity have driven the recognition that lymph-targeted delivery has the potential to… CONTINUE READING